Salvia, salvinorins & derivatives
Salvia divinorum, aka 'salvia,' emerges as a recreational drug
Salvinorin A found to be the primary psychoactive compound; several salvinorins are identified
Salvinorin A acts as an agonist at the kappa-opioid receptor
Salvinorin A demonstrates antinociceptive effects in mice
Potential therapeutic value is discussed prospectively
Chavkin et al. (2004). Salvinorin A, an active component of the hallucinogenic sage Salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations. The Journal of Pharmacology and Experimental Therapeutics.
Pichini et al. (2005). Quantification of the plant-derived hallucinogen Salvinorin A in conventional and non-conventional biological fluids by gas chromatography/mass spectrometry after Salvia divinorum smoking. Rapid Communications in Mass Spectrometry.
Zhang et al. (2005). Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: Agonist actions at kappa opioid receptors. Psychopharmacology.
Ansonoff et al. (2006). Antinociceptive and hypothermic effects of salvinorin a are abolished in a novel strain of κ-opioid receptor-1 knockout mice. The Journal of Pharmacology and Experimental Therapeutics.
Capasso et al. (2006). The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A inhibit enteric cholinergic transmission in the guinea-pig ileum. Neurogastroenterology and Motility.
Harding et al. (2006). Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A. Journal of Natural Products.
Butelman et al. (2007). Effects of salvinorin a, a κ-opioid hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high κ-receptor homology to humans. The Journal of Pharmacology and Experimental Therapeutic.
Vortherms et al. (2007). Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor. The Journal of Biological Chemistry.